DOID seminar series (hybrid)
join us for the next seminar in the series
Bio: Dr Benjamin Gewurz
Ben Gewurz is an Associate Professor at the Brigham & Women’s Hospital, Harvard Medical School and the Broad Institute. Ben received a PhD in Immunology from Harvard Medical School, where his doctoral studies with Hidde Ploegh and Don Wiley focused on human cytomegalovirus evasion of the MHC Class I antigen presentation pathway. His post-doctoral fellowship with Elliott Kieff characterized pathways by which the Epstein-Barr virus (EBV) oncogene LMP1 activates NF-kB to regulate host target genes. His laboratory uses genetic, proteomic and metabolomic approaches to characterize EBV/host interactions, including epigenetic mechanisms that regulate viral genome programs. EBV uses a biphasic lifecycle, in which it alternates between latency and lytic reactivation states to successfully colonize the B-cell compartment and to spread between hosts. His lab has used human genome-wide CRISPR/Cas9 screens to identify host factors critical for the maintenance of EBV latency within infected B-cells. These highlighted roles of MYC and a complex containing the histone demethylase LSD1 in control of viral non-coding RNAs, which in turn regulate 3-dimensional EBV genomic architecture and the lytic switch.
for general enquiries contact; @Mallu, Yasmin
or online: via Microsoft Teams – details to follow
